AGRICULTURAL GENETICS:
Gene Mutation Provides More Meat on the HoofSteven Dickman
(SUMMARY)
Scientists have for the first time identified a gene that influences an economically important trait in beef cattle. When mutated, the gene, which codes for a protein called myostatin, leads to a phenomenon called "doubling muscling" in which the muscles grow much larger than normal, while still retaining their tenderness. Because the gene has also been found in nine additional animals, including the pig, turkey, and chicken, the discovery may lead to development not only of meatier strains of cattle but of other domestic animals as well.
The full text of the article provides various additional details: names of discoverers and leaders of research groups (Sejin Lee and Alexandra McPherron of Johns Hopkins; Tim Smith of USDA and John Baff of New Zealand; Michel Georges of University of Liège), mention of an "in press" article in Proceedings of the National Academy of Sciences [turns out to be Proc. Natl. Acad. Sci. USA, Vol. 94, pp. 12457-12461, November 1997], of an article by Lee and McPherron published in May [but with no citation], and the sentence
Discovered just 4 months ago in mice by Lee and his graduate student Alexandra McPherron, myostatin normally serves to limit skeletal muscle growth... mutations block its activity and the animal's muscles grow larger --but without harming meat quality..." (pg 1922)
myo- mi;o, combining f. Gr. muj (gen. muo-j) muscle, in many scientific terms
If my task was to gather more information, where would I begin and how would I proceed? Clearly, I need to
A search in Annie for the keyword "muscle" turns up 40 items --not too many to look through-- and these look especially promising (relatively recent, too), and are at the very least worth a look:
AUTHOR Matthews, Gary G., 1949- TITLE Cellular physiology of nerve & muscle / Gary G. Matthews. PUBLISHER Palo Alto : Blackwell Scientific Publications, c1985. SUBJECT Nerves -- Cytology. Muscles -- Cytology. Electrophysiology. Neural conduction. Cell physiology. Science Library QP363 .M38 1985 TITLE Molecular basis of morphogenesis / editor, Merton Bernfield. PUBLISHER New York : Wiley-Liss, c1993. Science Library QH511 .S6 no.51 (has sections on Myogenic factor gene expression in mouse somites and limb buds, Myogenic lineages within the developing somite, and Positional specification during muscle development) TITLE Skeletal muscle / section editor, Lee D. Peachey, associate editor, Richard H. Adrian, executive editor, Stephen R. Geiger. PUBLISHER Bethesda, Md. : American Physiological Society ; Baltimore : SERIES Handbook of physiology ; section 10. Science-Reference QP6 .H25 1977 sect. 10 AUTHOR McComas, Alan J. TITLE Skeletal muscle : form and function / Alan J. McComas. PUBLISHER Champaign, IL : Human Kinetics, c1996. SUBJECT Striated muscle -- Physiology. Science Library QP321 .M3376 1996
The tool of choice is UnCover, a database of 17,000-odd tables of contents of (mostly) scholarly journals. And sure enough, a search for 'mcpherron' yields this:AUTHOR(s): McPherron, A.C. Lawler, A.M. Lee, S-J. TITLE(s): Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member. In: Nature. MAY 01 1997 v 387 n 6628 Page: 83As fate would have it, when I first went looking for it this issue of Nature was shown in Annie as being bound... but it has returned and I was able to find and photocopy the article