I did a keyword search: su:double muscling and discovered the
IDentifier 'double muscling', and so did a search for that:
SEARCH STRING: id:double muscling
ACCESSION NO: IND20559514
AUTHOR: Amory, H. McEntee, K. Linden, A.S. Desmecht, D.J.M.
Beduin, J.M. D'orio, V. Lekeux, P.M.
TITLE: Comparative assessment of right ventricular performance from
the pressure-volume relationship in double-muscled and
conventional calves.
SOURCE: Canadian journal of veterinary research = Revue canadienne de
recherche veterinaire. Apr 1995. v. 59 (2) p. 135-141.
PUBLISHER: [Ottawa, Ont. : Canadian Veterinary Medical Association, 1986-
STATE/COUNTRY: Ontario
DATE: 1995 04
LANGUAGE: English (Summaries or abstracts in French)
PUB TYPE: Article
PUB AGENCY: Non-US Imprint, not FAO
SUBFILE/LOCAT: DNAL IND
STANDARD NO: ISSN: 0830-9000
IDENTIFIERS: Ventricular volume; Calves.; Ventricles.; Cardiac output.;
Blood pressure.; Blood volume.; Capacity.; Myocardium.;
Muscle contraction.; Double muscling.; Comparisons.
SUBJ CATEGORY: L600 ANIMAL PHYSIOLOGY AND BIOCHEMISTRY
ACCESSION NO: IND20549608
AUTHOR: Hornick, J.L. Eenaeme, C. van. Gauthier, S. Baldwin, P.
Istasse, L.
TITLE: Glucose, alpha-amino nitrogen, and amino acid exchange across
the hindlimb in young double-muscled type bulls maintained at
two growth rates.
SOURCE: Canadian journal of animal science. June 1996. v. 76 (2) p.
193-202.
PUBLISHER: Ottawa : Agricultural Institute of Canada, 1957
STATE/COUNTRY: Ontario
DATE: 1996 06
LANGUAGE: English (Summaries or abstracts in French)
PUB TYPE: Article
PUB AGENCY: Non-US Imprint, not FAO
SUBFILE/LOCAT: DNAL IND
STANDARD NO: ISSN: 0008-3984
ABSTRACTS: The effect of growth rate and protein supplementation on
muscle metabolism of eight bulls from the Belgian Blue breed,
double-muscled type, was investigated by the arterio-venous
difference technique. A low growth (LG) group was maintained
at a low growth rate over 36 d, and a rapid growth (RG) group
for 28 d before receiving a fattening diet allowing for a
rapid growth. At the end of the RG period the RG bulls
received a supplement of protected soybean meal. Animals were
fitted with an aortic ultrasonic blood flow probe and with
catheters in the aorta and the vena cava. The blood flow in
the hindlimbs of bulls varied greatly by time of the day but
was higher in the RG group. The RG group had a higher arterio-
venous difference (AVD) and uptake of alpha-amino nitrogen
while AVD in essential amino acids was four times higher and
uptake eight times higher. Significant higher AVD or uptake
was observed in individual amino acids such as leucine,
isoleucine and lysine. The supplementation with protected
soybean meal had significant negative effect on the uptake of
several amino acids. It was concluded that caution should be
exercised when measuring punctually blood flow in muscle
tissue, for example by dilution techniques. At high growth
rate, the requirements for amino acids are larger than for
glucose. Excess protein provides no additional benefit.
IDENTIFIERS: Bulls.; Growth rate.; Protein supplements.; Protected
protein.; Soybean oilmeal.; Blood flow.; Glucose.;
Metabolism.; Amino nitrogen.; Amino acids.; Limbs.; Belgian
blue.; Double muscling.
SUBJ CATEGORY: L600 ANIMAL PHYSIOLOGY AND BIOCHEMISTRY
L500 ANIMAL NUTRITION
ACCESSION NO: IND20472344
AUTHOR: Gerrard, D.E. Grant, A.L. Anderson, D.B. Lemenager, R.P.
Judge, M.D.
TITLE: In-vivo analysis of serum-borne growth factors in developing
co-twinned fetuses.
SOURCE: Journal of animal science. June 1995. v. 73 (6) p. 1689-1693.
PUBLISHER: Champaign, Ill. : American Society of Animal Science.
STATE/COUNTRY: Illinois
DATE: 1995 06
LANGUAGE: English
PUB TYPE: Article
PUB AGENCY: US Imprint, not USDA
SUBFILE/LOCAT: DNAL IND
STANDARD NO: ISSN: 0021-8812
ABSTRACTS: Double-muscled fetuses develop more muscle fibers than normal-
muscled fetuses. To examine whether serum growth factors
modulate muscle development in cattle, twin pregnancies were
induced in eight Holstein heifers using embryos from Belgian
Blue and Holstein genetics representing heavy (HM) and light
(LM) muscled cattle, respectively. Twin combinations were 1)
two pairs of Belgian Blue fetuses that were designated as HM
(HM), 2) two pairs of Holstein fetuses that were designated
as LM (LM), and 3) four pairs of mixed fetuses; the four
Holstein fetuses were designated as LM (HM) and the four
Belgian Blue fetuses were designated as HM (LM). Pregnancies
were terminated at 175 +/- 5 d after conception and fetuses,
with evidence of vascular anastomosis, were dissected.
Carcass weights were greatest (P < .05) for HM fetuses. Total
bone and individual femur weights were greatest (P < .05) for
LM (LM) fetuses. Total skeletal muscle mass and mass of
semitendinosus, quadriceps femoris, infraspinatus, and
longissimus muscles were in the order of HM (HM) > HM (LM) >
LM (HM) = LM (LM) (P < .05). Estimated apparent muscle fiber
number determined from a cross-section of semitendinosus
muscle was in the order of HM (LM) > HM (HM) > LM (HM) = LM
(LM) (P < .05). These data show that the presence of a co-
twinned fetus with a lower genetic propensity for muscle
development reduces the capacity of heavily muscled fetuses
to develop muscle mass by 175 d after conception and strongly
support the idea that blood-borne factors regulate muscle
hypertrophy in fetal cattle.
IDENTIFIERS: Cattle.; Double muscling.; Twins.; Fetus.; Skeletal muscle.;
Muscle weight.; Hyperplasia.; Holstein-friesian.; Belgian
blue.; Body weight.; Bone weight.; Femur.; Length.; Liver.;
Muscles.; Muscle fibers.; Area.; Fetal growth.; Blood
circulation.
SUBJ CATEGORY: L600 ANIMAL PHYSIOLOGY AND BIOCHEMISTRY
ACCESSION NO: IND20431002
AUTHOR: Lekeux, P. Amory, H. Desmecht, D. Gustin, P. Linden, A.
Rollin, F.
TITLE: Oxygen transport chain in double-muscled Blue Belgian cattle.
SOURCE: The British veterinary journal. Sept/Oct 1994. v. 150 (5) p.
463-471.
PUBLISHER: London : Bailliere Tindall.
STATE/COUNTRY: England
DATE: 1994 09
LANGUAGE: English
PUB TYPE: Article
PUB AGENCY: Non-US Imprint, not FAO
SUBFILE/LOCAT: DNAL IND
STANDARD NO: ISSN: 0007-1935
ABSTRACTS: The physiological peculiarities of the oxygen transport chain
in double-muscled Blue Belgian cattle are described. The
investigations performed at several levels of the oxygen
transport chain suggest that the increased susceptibility of
these cattle to stress, resulting mainly in respiratory
diseases, is due to an insufficient functional reserve
capacity mainly involving the pulmonary and cardiovascular
systems. The resulting lack of 'functional hardiness' of the
oxygen transport chain is seen in those double-muscled cattle
which do not react in an appropriate or predictable way when
submitted to a hostile environment.
IDENTIFIERS: Cattle.; Oxygen transport.; Double muscling.; Cattle breeds.;
Stress.; Susceptibility.
SUBJ CATEGORY: L600 ANIMAL PHYSIOLOGY AND BIOCHEMISTRY
L200 ANIMAL GENETICS
ACCESSION NO: IND20409333
AUTHOR: Armory, H. Desmecht, D.J.M. Linden, A.S. McEntee, K.
Rollin, F.A. Beduin, J.M.L. Genicot, B.C. D'orio, V.
Lekeux, P.M.
TITLE: Comparison of cardiac function in double-muscled calves and
in calves with conventional muscular conformation.
SOURCE: American journal of veterinary research. Apr 1994. v. 55 (4)
p. 561-566.
PUBLISHER: Schaumburg, Ill. : American Veterinary Medical Association.
STATE/COUNTRY: Illinois
DATE: 1994 04
LANGUAGE: English
PUB TYPE: Article
PUB AGENCY: US Imprint, not USDA
SUBFILE/LOCAT: DNAL IND
STANDARD NO: ISSN: 0002-9645
ABSTRACTS: During growth, central venous, right ventricular, pulmonary
arterial, Pulmonary capillary wedge, and systemic arterial
pressures, heart rate, and cardiac Output were repeatedly
measured in 41 Friesian calves, considered as having
conventional muscular conformation, and in 19 Belgian White
and Blue double-muscled calves. A total of 123 and 70
recordings were collected in conventional and double-muscled
calves, respectively. These circulatory indices were
calculated: stroke volume, cardiac and stroke indices,
pulmonary and systemic pulse pressures, pulmonary and
systemic vascular resistance indices, and right and left
ventricular work indices. Results indicated that systemic
arterial and pulse pressures, as well as cardiac output,
stroke volume, cardiac and stroke indices, and right and left
ventricular work indices were significantly (P less than or
equal to 0.05 to 0.001) lower but, in contrast, pulmonary and
systemic vascular resistance indices were significantly (P
less than or equal to 0.001) higher in double-muscled than in
conventional calves. Right-sided vascular pressures and heart
rate were similar in the 2 groups. These results indicated
that global cardiac performance may be considerably poorer in
double-muscled calves. Diminished cardiac performance of
double-muscled calves appears to be related neither to
relative bradycardia nor to reduced ventricular preload. The
potential role of increased ventricular afterload or of
reduced myocardial contractility in double-muscled cattle
should be determined by direct measurements.
IDENTIFIERS: Belgian white and blue; Calves.; Double muscling.; Friesian.;
Cattle breeds.; Cardiovascular system.; Hemodynamics.; Breed
differences.
SUBJ CATEGORY: L600 ANIMAL PHYSIOLOGY AND BIOCHEMISTRY
L200 ANIMAL GENETICS
And one from BIOSIS:
SEARCH STRING: su:double muscling
BIOSIS NO: 90048660
AUTHOR: QUINN L S; ONG L D; ROEDER R A
CORP. SOURCE: DEP. BIOLOGICAL STRUCTURE, SM-20 UNIV. WASHINGTON, SEATTLE,
WASH. 98195.
TITLE: PARACRINE CONTROL OF MYOBLAST PROLIFERATION AND
DIFFERENTIATION BY FIBROBLASTS
SOURCE: DEV BIOL : DEVELOPMENTAL BIOLOGY 140(1). 8-19.
DATE: 1990.
STANDARD NO: DEBIA
LANGUAGE: English
ABSTRACT: Double-muscling (DM) is a hereditary (apparently single-gene)
skeletal muscle hyperplasia which occurs in beef cattle. In
order to investigate the cellular basis of this phenotype,
cell culture from developing muscle tissue of normal an DM
fetal calves were studied. In cultures composed of both
myogenic cells and nonmyogenic, fibroblast-like cells, DM
myoblasts exhibited a prolonged proliferative phase. This
resulted in delayed, but increased production of fused
myotubes in the DM cultures. "Conditioned" media experiments
indicated that the fibroblast-like cells in the cultures
produced soluble myoblast growth factor activity. Both normal
and DM fibroblast-like cells produced the growth factor
activity, but the mutant fibroblast-like cells produced a
greater level of such activity. The conditioned media failed
to increase proliferation of bovine muscle fibroblasts and did
not stimulate quiescent Swiss 3T3 cells to divide, indicating
that the myoblast trophic activity is distinct from bFGF or
PDGF. Also, the myotrophic activity present in the conditioned
media acted in an additive fashion with saturating doses of
bFGF and of IGF-1, suggesting that the activity is not due to
either of these known myogenic growth factors. Both normal and
DM fibroblast-like cells produced myoblast trophic activity
when the cells were proliferating, but did not produce
myotrophic activity when the fibroblasts were mitotically
quiescent. These findings indicate that the proliferative
state of the connective tissue cells in muscle may have a
controlling influence on myoblast proliferation and
differentiation during development.
DESCRIPTORS: CATTLE DOUBLE-MUSCLING HEREDITARY MUSCLE DEFECT MYOGENESIS
CELL CULTURE
SUPER TAXA: Animals; Chordates; Vertebrates; Nonhuman Vertebrates;
Mammals; Nonhuman Mammals; Artiodactyls