wetware /wet'weir/ [prob. from the novels of Rudy Rucker] n.
  1. The human nervous system, as opposed to computer hardware or software. "Wetware has 7 plus or minus 2 temporary registers."
  2. Human beings (programmers, operators, administrators) attached to a computer system, as opposed to the system's hardware or software. See liveware, meatware.
(from The Jargon File)
(the bit about "7 plus or minus 2 temporary registers" is an allusion to a famous article by George Miller, more than 35 years old now, called "The Magical Number 7 Plus or Minus 2", which suggests that we humans have an effective limit of between 5 and 9 somethings --numbers, letters, etc.-- that we can hold in memory at once without some kind of chunking. Typical computer nerd humor... See a discussion thread from Steven Harnad's cognition empire for further elaboration)
Andy Rundquist has used the concept to name his company. Here's his explanation, along with a nice quote from Rudy Rucker's original.
How does one capture the attention of an undergraduate audience, such that they become personally engaged in what you are trying to show and tell? This perennial problem vexes all college teachers, and most evolve more-or-less satisfactory toolkits, often based on amalgams of humor and surprise. I often have occasion to teach the use of computers as information access tools, and face the hurdles of unfamiliar hardware and software conventions which students must master in order to get to the real reason to use computers. Why bother, except for compulsion? Introduction of the concept of wetware provides a focus for the personal responsibility that lies at the heart of taking charge of one's own education, and reduces to a handy formula:

Everyone is responsible for his or her own wetware.

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