test interpretations from a lab site (with some references)
"Due to a complex founder effect, the province of Quebec has an unusually high prevalence of tyrosinemia, particularly in the Saguenay/Lac Saint-Jean region (where the prevalence is 1 in 1850)..."
Why are some mutations more common in some population groups?
A good basic introduction to some aspects of epidemiological demography, or demographic epidemiology, with some of the tricky bits nicely explained.
Children's Liver Alliance tyrosinemia links
Directed Case Study: The Death of Baby Pierre - A Genetic Mystery (Clyde Freeman Herreid, SUNY Buffalo)
abstract of an article from Hepatology ("Official Journal of the American Association for the Study of Liver Diseases")
slide images from Metabolic Disorders of the Liver in the Age of Transplantation, Presented at the UPMC Diagnostic Pathology Conference, January 2, 1997 (Ronald Jaffe, M.B., B.Ch.)
Defects in Amino Acid Metabolism (leads to OMIM articles)