RECORD NO.:  95172532
       AUTHOR:  Ekstrom TJ
      ADDRESS:  Department of Clinical Neuroscience, Karolinska Hospital, 
                Stockholm, Sweden.
        TITLE:  Parental imprinting and the IGF2 gene.
       SOURCE:  Horm Res (GBI), 1994; 42 (4-5): 176-81
     LANGUAGE:  English
 COUNTRY PUB.:  SWITZERLAND
 ANNOUNCEMENT:  9506
    PUB. TYPE:  JOURNAL ARTICLE; REVIEW; REVIEW, TUTORIAL
 NUMBER REFS.:  38
     ABSTRACT:  The phenomenon of parental imprinting has become 
                increasingly important in disciplines such as evolution, 
                genetics, molecular biology, embryology and pathology. 
                Principally, parental imprinting refers to a parent-of-
                origin dependent expression of a subset of autosomal loci, 
                independent of the sex of the offspring. Today, at least 
                seven such loci have been identified, including the human 
                IGF2 gene. It appears that the set of imprinted genes is not 
                always identical between the species, although the 
                importance of maintaining this kind of gene regulation is 
                evolutionarily conserved. It is particularly interesting 
                from the clinical point of view that a number of human 
                diseases, such as the Beckwith-Wiedemann and Prader-
                Willi/Angelman syndromes, appear to involve unbalanced 
                parental contributions of imprinted loci. We show here that 
                the four different human IGF2 promoters are expressed mono- 
                and/or biallelically in complex patterns in postnatal liver 
                specimens.
MESH HEADINGS:  *Genomic Imprinting; Insulin-Like Growth Factor II--genetics 
                (*GE); Fetal Development--genetics (GE); Genes, Suppressor, 
                Tumor; Liver--metabolism (ME); Mice; Models, Genetic; 
                Promoter Regions (Genetics); Animal; Female; Human; Male; 
                Support, Non-U.S. Gov't
  GENE SYMBOL:  IGF2; H19
CHEMICAL SUBS:  67763-97-7 (Insulin-Like Growth Factor II)
 STANDARD NO.:  0301-0163
        DATES:  Entered 950330