(GENOM** OR PARENTAL) W/1 IMPRINTING
 
Your search request has found 4 PATENTS through Level 1.

                              LEVEL 1 - 4 PATENTS
1. 5,405,760, Apr. 11, 1995, Process for producing recombinant McrBC
endonuclease and cleavage of methylated DNA, Raleigh, Elisabeth A., West
Somerville, Massachusetts Hauck, Ellen S., Lowell, Massachusetts
 
2. 5,391,575, Feb. 21, 1995, Method for treating neurofibromatosis, Burzynski,
Stanislaw R., 20 W. Rivercrest, Houston, Texas 77042
 
3. 5,296,371, Mar. 22, 1994, DNA encoding spiroplasma sp. dna methylase, Razin,
Aharon, Jerusalem, Israel Rottem, Shlomo, Jerusalem, Israel Renbaum, Pinhas F.,
Jerusalem, Israel
 
4. 5,057,420, Oct. 15, 1991, Bovine nuclear transplantation, Massey, Joseph M.,
College Station, Texas

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                            LEVEL 1 - 1 OF 4 PATENTS
                                   5,405,760
 
                        <=1>  GET 1st DRAWING SHEET OF 11
 
                                 Apr. 11, 1995
 
            Process for producing recombinant McrBC endonuclease and
                           cleavage of methylated DNA
 
INVENTOR: Raleigh, Elisabeth A., West Somerville, Massachusetts
Hauck, Ellen S., Lowell, Massachusetts
 
 SUM:
   ... Science, 252:1097-1102 (1991); Silva & White, Cell, 54:145-152 (1988)).
 
   Some genetic diseases are thought to result from the establishment
("imprinting") of aberrant methylation patterns during gametogenesis (egg and
sperm development). The term genomic imprinting  (Chaillet et al., Cell,
66:77-83 (1991); Solter, Annu. Rev. Genet., 22:127-146 (1988); Surani et al.,
Philos. Trans. Roy. Soc., (Lond) B 326, 313- ...

The term genomic imprinting (Chaillet et al., Cell, 66:77-83 (1991); Solter, Annu. Rev. Genet., 22:127-146 (1988); Surani et al., Philos. Trans. Roy. Soc., (Lond) B 326, 313-327 (1990)) refers to the reversible inactivation of a gene, depending on whether the gene is transmitted through the male or the female parent. That is, a gene may be expressed when it has been inherited from the mother but not when it has been inherited from the father. An inactive gene inherited by a daughter from her father will be reactivated when she passes it to her children (since she is the mother). In other cases, imprinting may occur in the mother, not in the father. Only some genes are subject to imprinting.

In consequence of imprinting, two "defective" genes may be inherited, even when one is wild-type (normal) in sequence. This happens if the wild-type copy is imprinted and thus inactivated, while the non-imprinted copy is mutated at the sequence level; a genetic disease may then result. Diagnosis of genetic disease in such cases will not be possible by the usual sequence-based methods, because non-diseased and diseased individuals cannot be distinguished on the basis of sequence. A non-diseased heterozygote with a mutated, imprinted copy and a wild-type, non-imprinted copy will be indistinguishable from a diseased heterozygote with an wild-type, imprinted copy and a mutated, non-imprinted copy. DNA methylation patterns are closely related to imprinted state, and imprinting may in fact be the same as methylation. Resetting of the imprinted state occurs during gametogenesis (Chaillet, et al., Cell 66:77-83 (1991)) and is associated with changes in DNA methylation of the sequence of the gene and near it (Holliday, R., Science, 238:163-170 (1987); Reik et al., Nature, 328:248-251 (1987); Silva & White, Cell, 54:145-152 (1988)).